Hunter Hacker

 >the development process and evaluation of guidelines should focus on outcomes, the most important for consumers (quality of life, survival)

--researcher's brochure --protocol of clinical research --information for the subject of the study and the form of informed consent --clinical trial reports --individual registration card

--The Constitution of the Republic of Kazakhstan --state standard "Good Clinical Practice" --state standard "Good laboratory practice" --Convention on Human Rights and Biomedicine --Helsinki Declaration of the World Medical Association --The World Health Organization committees of ethics, conducting an examination of biomedical research

--high-quality research data --international cooperation --latest information --good structuring of information --shortens the search and evaluation time

--universality of access --international coverage --indexing based on subject headings --search by publication type --quality filters are available

--lack of full texts --reflects the bias of publications --not always available --sometimes uncomfortable to use --it's hard to get foreign articles

--a wide range of indexed logs --regular update --time saving --usability --free text search --advanced search tools

--structured abstracts --comments of independent experts --critical assessments of evidence --methodologically reliable studies --strict selection criteria for information

--do not always contain reviews --roads --access to libraries is limited --it takes a long time to search and view --there are too many of them --bias of publications

--quickly become obsolete --access to libraries is limited --it takes a long time to search and view

--AND --OR --NOT

--medication correction carried out --control drug therapy was conducted --the goal of drug therapy on the level of care

--rationality dose regime --rational ways of selecting injection drugs --rationality of the exchange rate regime

--conformity assessment of medical therapy approved clinical protocols of diagnosis and treatment, the main purpose PM --evaluation of selection Message for the underlying disease and taking into account comorbidities --evaluation dosing regimen and selection of drug administration routes --evaluation of the interaction of drugs, the risk of unwanted side effects --evaluation of clinical efficacy

--type (design) study --number of studies and the number of the included patients --pointedness results --clinical significance of the effect and its variations --applicability of study results to the population of interest

--quality --quantitative

--individual health --family health --health groups of people united by any sign --public health

--preparatory --data collection and statistical processing of the primary --statistical and logical analysis of the information received --formulation of conclusions

--high quality scientific research data --clinical judgment and personal professional experience of the doctor --individual characteristics of the patient

--allows reducing the chance of systematic errors --allows to increase the sample size and to reduce the dispersion --inconsistency of data is possible to obtain a statistically significant result

--responds to a clearly defined clinical questions --compiled on the basis of the search is absolutely all sources of information in different languages --analyzes the accuracy of all data on a special technique --regularly updated (updated with new research results) --adds a meta-analysis using only valid data

--reviews --clinical guidelines --analyzes the decision-making --economic analyzes

--randomized controlled trials --cohort studies --research "case-control" --cross study

--formulated clinical questions --object - the results of original research --critical analysis and evaluation of original research --the reduction of systematic and random errors

--case report --descriptive study --low level of Evidence

--cohort study --prospective study --analytical study

-- Evidence – based Medicine Reviews from Ovid Technologies -- Cochrane Library -- Best Evidence -- Medline

--prospective --retrospective --mixed

--identification of any interactions with medications --detection and identification of previously unknown adverse reactions, and risk factors --the impact on survival --the use of drugs in other age groups or categories of patients

--Thousands of patients --Multicenter large studies in different patient populations --Application methods of randomization, stratification, "blinding" --Economic evaluation of treatment methods

--Selection of the multiplicity of the drug --The first controlled study involving patients --Determining the optimal dosage level of new drug --200-600 patients

--participate animals --mutagenic toxicity --teratogenic toxicity --carcinogenic toxicity

--involved healthy volunteers --tolerability of a new drug --pharmacokinetic Parameters --pharmacodynamic effects

--lowering glucose levels --functional activity --blood sugar levels --blood pressure level

--mortality --disability --serious complications --serious side effects

--reduction in the number of deaths --increase in life expectancy --disability --quality of life --reduction in the duration of hospitalization

--randomization --stratification --selection of pairs

--study methods of treatment --study methods of prevention

--randomization --blinding (masking) --follow-up (observation of all patients to the end of the study) --comparison of outcomes (etiology, reasons, efficiency) in the test and control groups after intervention --the most powerful way to assess the effectiveness

-randomization (well done) --observation of patients to the end of the study (80%) --double (triple) blinding --similarity of the main indicators of the groups at the beginning of the study --a significant statistical difference of indicators between the groups at the end of the study

- long-term alcohol intake\

- 10-20 human

- choice of theme

- Analysis of "expenses - benefit (benefits)"

- Analysis of "expenses - utility (utility)"

- Analysis of "expenses - effectiveness"

- Analysis of "expenses minimization"

- Analysis of the "cost of illness"

- about a good level of medical therapy

- about the high level of drug therapy

- glycemic control group of patients at different time points

-95% or more

-growth

-sex

-citation index

-articles from peer-reviewed journal with a high index of citation

-development and application of effective methods of clinical research

-clinical epidemiology

- a randomized controlled trial

- application of influenza vaccine

- reduction in the rate of exacerbation

- absence of treatment

- Patients with pneumonia over 60 years and have a concomitant disease - chronic obstructive pulmonary disease (COPD)

- a randomized controlled trial

- application of IGCS

- reduction in the rate of exacerbation

- Patients with COPD

- compared with no treatment

- Discomfort

- cash ("pocket") expenses of patients (eg, payment of services at the health facility

- transportation costs (when moving patients health, and personal or public transport)

- economic losses due to lost productivity in the workplace of the patient

- economic losses due to lost productivity in the workplace of the patient

- the cost of professional health services (fee for medical consultations, as well as the payment of the working time of doctors or nurses)

- the cost of maintaining a patient in a hospital, or the cost of services at home, including nurses

- the foundation to improve the efficiency of treatments (establishment of standards of care and protocols, patient management) and sustainable financing

- improving the quality of clinical decisions

- improve the prognosis of the disease, reducing morbidity and mortality, improving quality of life, or certain aspects of it

- The Cochrane Library

- The Cochrane Library

- The Cochrane Library

- Cohort study

- nonrandomized study with simultaneous control

- Study of the type “case-control”

- Cohort study

- Whether the ban will reduce the sale of sweets in the school cafeteria the number of overweight children

- categorically not recommended

- Cohort study

- Cohort study

- message about severe side effects of a new drug

- cohort study

- Study “case-control”

- Systematic review and meta-analysis

- Systematic review

- a randomized controlled trial

- Description of case

- transverse study

- transverse cross-sectional study

- a randomized controlled trial

- a randomized controlled trial

- pharmacoepidemiology

- pharmacoeconomics

- Good Manufacturing Practice (GMP)

- medicine, based on the technology of gathering, critical analysis

- analysis, estimation of rationality and quality of drug therapy

- double-blind, randomized, controlled clinical trial

- randomized clinical trial

- study Design

- Methods of study

- introduction

- systematic review

- animal studies